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Role of c‐Met expression on prognosis of head and neck cancer: A literature review and meta‐analysis
Author(s) -
Li Lei,
Sun Zhijun,
Huang Xin,
Li Xiao,
Sun Lihua,
Zhang Lei,
Zhang Xiaodan,
Ye Longwei,
Yuan Jie,
Mao Limin,
Li Guolin
Publication year - 2019
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.25655
Subject(s) - medicine , head and neck cancer , hazard ratio , confidence interval , odds ratio , oncology , meta analysis , head and neck , cancer , surgery
The prognostic role of c‐Met expression in patients with head and neck cancer were controversial among different studies. Thus, we performed a meta‐analysis to evaluate the relationships between c‐Met expression and survival and clinical parameters of head and neck cancer patients. Summary hazard ratio (HR) and 95% confidence intervals (CIs) were calculated to analyze the correlations between c‐Met expression and overall survival (OS), and disease‐free survival (DFS). Furthermore, odds ratios (ORs) and 95% CIs were used to describe the relationships between c‐Met expression and different clinicopathological parameters. A total of 2417 patients from 19 studies were enrolled in the final analysis. The results showed that patients with higher c‐Met expression had a poor OS (HR, 1.65; 95% CI, 1.20‐2.27) and DFS (HR, 1.48; 95% CI, 0.99‐2.20). In addition, c‐Met expression was associated with the N classification of patients with head and neck cancer. These results suggested that c‐Met expression was a risk factor for head and neck cancer, and increased c‐Met expression would be a predictor of a poorer prognosis for the patients.