Premium
Early onset oral tongue squamous cell carcinoma: Associated factors and patient outcomes
Author(s) -
Campbell Benjamin R.,
Sanders Courtney B.,
Netterville James L.,
Sinard Robert J.,
Rohde Sarah L.,
Langerman Alexander,
Mannion Kyle,
Kim Young J.,
Murphy Barbara A.,
Lewis James S.,
Warner Jeremy L.,
Smith Derek K.,
Lang Kuhs Krystle A.
Publication year - 2019
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.25650
Subject(s) - medicine , hazard ratio , odds ratio , tongue , confidence interval , etiology , snuff , proportional hazards model , incidence (geometry) , cancer , logistic regression , pathology , physics , optics
Background Incidence of oral tongue squamous cell carcinoma (OTC) is rising among those under age 50 years. The etiology is unknown. Methods A total of 395 cases of OTC diagnosed and/or treated at Vanderbilt University Medical Center between 2000 and 2017 were identified. Of those, 113 (28.6%) were early onset (age < 50 years). Logistic regression was used to identify factors associated with early onset OTC. Cox proportional hazards models evaluated survival and recurrence. Results Compared to typical onset patients, patients with early onset OTC were more likely to receive multimodality treatment (surgery and radiation; adjusted odds ratio [aOR], 2.7; 95% confidence interval [CI], 1.2‐6.3) and report a history of snuff use (aOR, 5.4; 95% CI, 1.8‐15.8) and were less likely to report a history of cigarette use (aOR, 0.5; 95% CI, 0.2‐0.9). Early onset patients had better overall survival (adjusted hazard ratio, 0.6). Conclusions This is the largest study to evaluate factors associated with early onset OTC and the first to report an association with snuff.