Prognostic and clinicopathological significance of  CTTN /cortactin alterations in head and neck squamous cell carcinoma: Systematic review and meta‐analysis | Zendy

RamosGarcía Pablo | Zendy; GonzálezMoles Miguel Ángel | Zendy; Ayén Ángela | Zendy; GonzálezRuiz Lucía | Zendy; RuizÁvila Isabel | Zendy; GilMontoya José Antonio | Zendy

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Prognostic and clinicopathological significance of CTTN /cortactin alterations in head and neck squamous cell carcinoma: Systematic review and meta‐analysis

Author(s) -

RamosGarcía Pablo,

GonzálezMoles Miguel Ángel,

Ayén Ángela,

GonzálezRuiz Lucía,

RuizÁvila Isabel,

GilMontoya José Antonio

Publication year - 2019

Publication title -

head and neck

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.012

H-Index - 127

eISSN - 1097-0347

pISSN - 1043-3074

DOI - 10.1002/hed.25632

Subject(s) - cortactin , medicine , oncology , basal cell , stage (stratigraphy) , head and neck squamous cell carcinoma , overall survival , head and neck , cell , pathology , head and neck cancer , cancer , biology , surgery , paleontology , genetics , cytoskeleton

Background To evaluate the prognostic significance of CTTN /cortactin alterations in head and neck squamous cell carcinoma (HNSCC). Material and methods We searched PubMed, Embase, Web of Science, and Scopus for studies published before May 2018. We conducted a meta‐analysis to quantify the impact of CTTN /cortactin alterations on clinicopathological and survival variables. Results Eighteen studies (1633 patients) met inclusion criteria. Quantitative evaluation revealed a strong association of CTTN /cortactin alterations with N+ status ( P < .001), higher T status ( P < .001), advanced clinical stage ( P < .001), high histological grade ( P = .001), and lower overall survival (OS) ( P < .001). We found heterogeneity in T status, histological grade, and OS and observed small‐study effects on N status and OS. In subgroup analyses, a significant association of CTTN amplification and cortactin overexpression with the above variables was preserved. The strongest association between CTTN /cortactin alterations and a worse outcome was observed in the subgroups of Asian patients and pharyngolaryngeal squamous cell carcinomas. Conclusions CTTN /cortactin alterations should be evaluated to predict the HNSCC prognosis.

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