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Importance of tumor budding grade as independent prognostic factor for early tongue squamous cell carcinoma
Author(s) -
Ebihara Yasuhiro,
Yoshida Saori,
Nakahira Mitsuhiko,
Kogashiwa Yasunao,
Enoki Yuichiro,
Kuba Kiyomi,
Inoue Hitoshi,
Minami Kazuhiko,
Yasuda Masanori,
Sugasawa Masashi
Publication year - 2019
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.25614
Subject(s) - tongue , medicine , hazard ratio , odds ratio , confidence interval , oncology , univariate analysis , multivariate analysis , lymph node metastasis , risk factor , basal cell , gastroenterology , metastasis , pathology , cancer
Background Factors involved in neck lymph node metastasis (NLM) and prognosis of early tongue squamous cell carcinoma (SCC) remain unknown. Methods We analyzed disease‐specific survival (DSS) and NLM including tumor budding grade (TBG) among 64 patients with cT1/2N0 tongue SCC. Results Univariate analysis of DSS of primary lesions uncovered significant differences in new cT, pT, new pT, pDiameter, venous infiltration, and TBG. Multivariate analysis selected only TBG3 as a predictor of NLM (odds ratio, 9.55; 95% confidence interval [CI], 1.80‐50.8; P = .008), and a prognostic factor for DSS (hazard ratio, 4.41; 95% CI, 1.34‐14.5; P = .02). Conclusion The sole predictor of NLM and the prognosis of early tongue SCC was TBG, indicating that it might help to select overwhelming risk patients.