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International validation of the revised European Organisation for Research and Treatment of Cancer Head and Neck Cancer Module, the EORTC QLQ‐HN43: Phase IV
Author(s) -
Singer Susanne,
Amdal Cecilie Delphin,
Hammerlid Eva,
Tomaszewska Iwona M.,
Castro Silva Joaquim,
Mehanna Hisham,
Santos Marcos,
Inhestern Johanna,
Brannan Christine,
Yarom Noam,
Fullerton Amy,
Pinto Monica,
Arraras Juan I.,
Kiyota Naomi,
Bonomo Pierluigi,
Sherman Allen C.,
Baumann Ingo,
Galalae Razvan,
Fernandez Gonzalez Loreto,
NicolatouGalitis Ourania,
AbdelHafeez Zeinab,
RaberDurlacher Judith,
Schmalz Claudia,
Zotti Paola,
Boehm Andreas,
Hofmeister Dirk,
Krejovic Trivic Sanja,
Loo Suat,
Chie WeiChu,
Bjordal Kristin,
Brokstad Herlofson Bente,
Grégoire Vincent,
Licitra Lisa
Publication year - 2019
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.25609
Subject(s) - cronbach's alpha , intraclass correlation , head and neck cancer , quality of life (healthcare) , discriminant validity , confirmatory factor analysis , reliability (semiconductor) , physical therapy , medicine , scale (ratio) , cancer , internal consistency , psychology , psychometrics , clinical psychology , statistics , mathematics , nursing , power (physics) , physics , structural equation modeling , quantum mechanics
Background We validated the new European Organisation for Research and Treatment of Cancer Quality of Life Head and Neck Module (EORTC QLQ‐HN43). Methods We enrolled 812 patients with head and neck cancer from 18 countries. Group 1 completed the questionnaire before therapy, and 3 and 6 months later. In group 2 (survivors), we determined test–retest reliability using intraclass correlation coefficients (ICC). Internal consistency was assessed using Cronbach's Alpha, the scale structure with confirmatory factor analysis, and discriminant validity with known‐group comparisons. Results Cronbach's alpha was >0.70 in 10 of the 12 multi‐item scales. All standardized factor loadings exceeded 0.40. The ICC was >0.70 in all but two scales. Differences in scale scores between known‐groups were >10 points in 17 of the 19 scales. Sensitivity to change was found to be sufficient in 18 scales. Conclusions Evidence supports the reliability and validity of the EORTC QLQ‐HN43 as a measure of quality of life.