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Impact of varying anatomic sites on advanced stage and survival of oral cancer: 9‐year prospective cohort of 27 717 cases
Author(s) -
Su William WangYu,
Su ChiuWen,
Chang DunCheng,
Chuang ShuLin,
Chen Sam LiSheng,
Hsu ChenYang,
Yen Amy MingFang,
Chiu Sherry YuehHsia,
Fann Jean ChingYuan,
Lee YiHuah,
Jeng YaChung,
Lee YiChia,
Chiu HanMo,
Chen Tony HsiuHsi,
Wang ChengPing,
Chen MuKuan
Publication year - 2019
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.25579
Subject(s) - medicine , tongue , buccal administration , cancer , hazard ratio , stage (stratigraphy) , odds ratio , confidence interval , dentistry , prospective cohort study , population , pathology , paleontology , environmental health , biology
Background To elucidate the impact of varying anatomic sites on advanced stage of and death from oral cancer. Methods A total of 27 717 oral cancers mainly from a population‐based visual inspection program in Taiwan from 2004 to 2009 was followed until the end of 2012. Results Using lip cancer as reference, the odds ratios (95% confidence interval [CI]) of advanced stage of cancer were 2.20 (1.92‐2.51) for tongue, 2.60 (2.28‐2.97) for buccal, 2.68 (2.20‐3.28) for floor of mouth, 2.96 (2.52‐3.47) for hard palate, 6.04 (5.17‐7.05) for gingiva, and 10.83 (9.20‐12.74) for oropharynx. The estimated hazard ratios (95% CI) for oral cancer death increased from 1.48 (1.31‐1.67) in buccal, 1.61 (1.43‐1.82) in tongue, 1.68 (1.41‐1.99) in floor of mouth, 1.79 (1.57‐2.05) in gingiva, 1.97 (1.71‐2.26) in hard palate, and 2.15 (1.89‐2.45) in oropharynx. Conclusion Different anatomic sites had variations in advanced stage of and death from oral cancer and need vigilant surveillance.