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Effects of APE1 Asp148Glu polymorphisms on OPMD malignant transformation, and on susceptibility to and overall survival of oral cancer in Taiwan
Author(s) -
Huang HsinI,
Chen ChungHo,
Wang ShengHung,
Wang LiHsuan,
Lin YingChu
Publication year - 2019
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.25576
Subject(s) - medicine , cancer , hazard ratio , malignant transformation , oncology , confidence interval , gastroenterology , cancer research
Background The associations between malignant transformation of oral potentially malignant disorders (OPMDs), oral cancer development and prognosis, and apurinic/apyrimidinic endonuclease 1 (APE1) functional polymorphisms are unclear. Methods Patients with OPMDs, patients with oral cancer, and healthy controls from the community were recruited to determine the effects of APE1 polymorphisms on malignant transformation, overall survival, and genetic susceptibility, respectively. Results The APE1 Asp148Glu polymorphisms significantly correlated with a high hazard ratio for OPMD malignant transformation (adjusted hazard ratio [AHR] = 2.29; 95% confidence interval [CI] = 1.44‐3.74) and low overall survival in oral cancer patients (AHR = 1.71, 95% CI = 1.11‐2.56) according to follow‐up and survival analysis. However, APE1 polymorphisms did not significantly correlate with development of oral cancer in the case‐control study and logistic regression analysis. Conclusions These results indicate that APE1 Asp148Glu polymorphisms may have indirect roles in increasing the OPMD malignant transformation rate and in decreasing overall survival in oral cancer patients.