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Competing mortality in oropharyngeal carcinoma according to human papillomavirus status
Author(s) -
Lop Joan,
García Jacinto,
López Montserrat,
Taberna Miren,
Mena Marisa,
Alemany Laia,
Quer Miquel,
León Xavier
Publication year - 2019
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.25559
Subject(s) - medicine , human papillomavirus , oncology , neoplasm , overall survival , cancer , carcinoma , pathology
Background The objective of the present study is to assess differences in the competing causes of death in patients with oropharyngeal carcinoma (OPC) as a function of the human papillomavirus (HPV) status. Methods We studied retrospectively 423 patients with OPC with known HPV status. Among the patients included in the study, 53 (12.5%) were HPV‐positive. We analyzed overall survival and competing causes of mortality according to the HPV status of the patients. Results Patients with HPV‐negative tumors had lower OPC cancer‐specific survival ( P = .0001), second primary neoplasm survival ( P = .0001), and noncancer‐related causes survival ( P = .13) than patients with HPV‐positive tumors. This resulted in significant differences in overall survival depending on HPV status ( P = .0001).Conclusion Conclusion: HPV‐positive OPC has a better overall survival than HPV‐negative OPC. Patients with HPV‐positive tumors presented a significant lower OPC cancer‐specific and second primary neoplasm mortality and a marginally nonsignificant lower noncancer mortality as compared to HPV‐negative tumors.