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Expression of CD44, EGFR, p16, and their mutual combinations in patients with head and neck cancer: Impact on outcomes of intensity‐modulated radiation therapy
Author(s) -
Slavik Marek,
Shatokhina Tetiana,
Sana Jiri,
Ahmad Parwez,
Kazda Tomas,
Selingerova Iveta,
Hermanova Marketa,
Cervena Renata,
Novotny Tomas,
Burkon Petr,
Smilek Pavel,
Horakova Zuzana,
Slampa Pavel,
Slaby Ondrej
Publication year - 2019
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.25533
Subject(s) - cd44 , medicine , oncology , head and neck squamous cell carcinoma , epidermal growth factor receptor , stage (stratigraphy) , radiation therapy , head and neck cancer , cohort , proportional hazards model , cancer , cell , biology , paleontology , genetics
Background Progress in radiation treatment of head and neck squamous cell carcinoma (HNSCC) deserves the studies focused on molecular predictors that would help to enhance individually tailored treatment. Methods p16/epidermal growth factor receptor (EGFR)/cluster of differentiation‐44 (CD44) was immunohistochemically analyzed in 165 HNSCC patients. Results In the entire group and the p16 negative cohort, better 3‐year overall survival and locoregional control correlated with p16 positivity, CD44, and EGFR negativity were observed. Combined analysis revealed the worst results in the CD44+/p16−, EGFR+/p16−, and EGFR+/CD44+ groups and in the EGFR+/CD44+ within p16 negative cohort. Multivariate analysis found tumor stage, Karnofsky index, p16, and CD44 as prognostic factors of overall survival and clinical stage, and p16 as a prognostic factor for locoregional control. Clinical stage and Karnofsky index affected overall survival and tumor stage. EGFR affected locoregional control in the p16 negative subgroup. Conclusion Our study confirmed the negative effect of CD44 and EGFR and the positive effect of p16 on radiotherapy results.