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Cortactin expression: Association with disease progression and survival in oral squamous cell carcinoma
Author(s) -
Horn Dominik,
Gross Madeleine,
Dyckhoff Gerhard,
Fuchs Jennifer,
Grabe Niels,
Weichert Wilko,
Herpel Esther,
HeroldMende Christel,
Lichter Peter,
Hoffmann Jürgen,
Hess Jochen,
Freier Kolja
Publication year - 2018
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.25515
Subject(s) - cortactin , cancer research , head and neck squamous cell carcinoma , cell , tissue microarray , medicine , cancer , oncology , head and neck cancer , biology , genetics , cytoskeleton
Background Cortactin (CTTN) is located on chromosome 11q13 and is associated with invasiveness in various cancer entities. CTTN protein expression could be a prognosticator of oral squamous cell carcinoma (OSCC) in terms of recurrence and survival. Methods CTTN‐dependent invasion was performed using migration assay in human papillomavirus‐negative head and neck squamous cell carcinoma (HNSCC) cells. Cortactin protein analysis in tissue microarrays was used for correlation with clinical parameters, as well as for survival analysis. Gene expression profiling in HNSCC cells was performed to unreveal CTTN signaling. Results Knockdown of CTTN in HNSCC cells showed less invasion in vitro. Gene expression profiling showed various deregulated genes known to be involved in progression. We confirmed the link between CTTN overexpression and progression in a large clinical cohort. High expression was associated with worse overall and progression‐free survival. Conclusions We propose CTTN for managing OSCC in terms of adjuvant therapy and aftercare. Furthermore, our study reveals new potential targets in CTTN signaling for individualized OSCC therapy.