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Serum matrix metalloproteinase 8 and tissue inhibitor of metalloproteinase 1: Potential markers for malignant transformation of recurrent respiratory papillomatosis and for prognosis of laryngeal cancer
Author(s) -
Pakkanen Pihla P.,
Aaltonen LeenaMaija,
Sorsa Timo A.,
Tervahartiala Taina I.,
Hagström Jaana K.,
Ilmarinen Taru T.
Publication year - 2019
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.25459
Subject(s) - recurrent respiratory papillomatosis , malignant transformation , metalloproteinase , tissue inhibitor of metalloproteinase , medicine , matrix metalloproteinase , matrix metalloproteinase 9 , cancer , laryngeal neoplasm , gastroenterology , pathology , disease
Background Biomarkers that could predict malignant transformation of recurrent respiratory papillomatosis (RRP) would be useful in patient follow‐up. We investigated whether serum matrix metalloproteinase 8 (MMP‐8) and tissue inhibitor of metalloproteinase 1 (TIMP‐1) could predict malignant transformation of RRP and whether they associate with survival in laryngeal squamous cell carcinoma (LSCC) without preexisting RRP. Methods We analyzed serum MMP‐8 (S‐MMP‐8) and serum TIMP‐1 (s‐TIMP‐1) in 114 patients: 55 were treated for RRP and 59 for LSCC without preexisting RRP. Five patients with RRP developed LSCC during follow‐up. Results Elevated S‐MMP‐8 level in RRP was associated with malignant transformation ( P = .01). Compared to patients with RRP, S‐MMP‐8 in patients with LSCC was significantly higher ( P < .001). Increased S‐TIMP‐1 level in LSCC was associated with poor overall survival ( P = .02) and recurrence‐free survival ( P = .05). Conclusion In RRP, high S‐MMP‐8 may predict malignant transformation. In LSCC, elevated S‐TIMP‐1 is connected to poor survival.