Premium
Effect of serpinE1 overexpression on the primary tumor and lymph node, and lung metastases in head and neck squamous cell carcinoma
Author(s) -
ArroyoSolera Irene,
Pavón Miguel Ángel,
León Xavier,
López Montserrat,
Gallardo Alberto,
Céspedes María Virtudes,
Casanova Isolda,
Pallarès Víctor,
LópezPousa Antonio,
Mangues María Antonia,
Barnadas Agustí,
Quer Miquel,
Mangues Ramón
Publication year - 2019
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.25437
Subject(s) - head and neck squamous cell carcinoma , medicine , lymph node , cancer research , lymph , stromal cell , lung cancer , primary tumor , oncology , metastasis , head and neck cancer , pathology , cancer
Background Serpin Family E Member 1 (SerpinE1) overexpression associates with poor clinical outcome in head and neck squamous cell carcinoma (HNSCC) patients. This study analyzed the role of serpinE1 in HNSCC dissemination. Methods We studied the phenotypic characteristics and dissemination of HNSCC cells overexpressing serpinE1 using an orthotopic model and the association between serpinE1 overexpression and clinicopathological variables in patients included in The Cancer Genome Atlas database. Results SerpinE1 overexpression increased proliferation, tumor budding, and the stromal component, while inhibiting apoptosis in primary tumors. It also enhanced the affectation and metastatic growth in lymph nodes, and the dispersion and growth of metastatic foci in the lung. High serpinE1 expression was associated with larger tumor size, undifferentiated tumors, lymph node metastasis, extracapsular spread, and the presence of perineural and angiolymphatic invasion. Conclusion SerpinE1 overexpression promotes tumor aggressiveness and metastatic dissemination to lymph nodes and lung consistently with its association with poor outcome in HNSCC patients.