Premium
Prognostic factors and survival in adenoid cystic carcinoma of the sinonasal cavity
Author(s) -
Mays Ashley C.,
Hanna Ehab Y.,
Ferrarotto Renata,
Phan Jack,
Bell Diana,
Silver Natalie,
Mulcahy Collin F.,
Roberts Dianna,
Abdelmeguid Ahmed Salama Ahmed,
Fuller Clifton D.,
Frank Steven J.,
Raza Shaan M.,
Kupferman Michael E.,
DeMonte Franco,
Su Shirley Y.
Publication year - 2018
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.25335
Subject(s) - medicine , adenoid cystic carcinoma , retrospective cohort study , radiation therapy , surgery , multivariate analysis , proportional hazards model , cancer , overall survival , single center , survival analysis , carcinoma
Background Optimal treatment and prognostic factors affecting long‐term survival in patients with sinonasal adenoid cystic carcinoma (ACC) have yet to be clearly defined. Methods We conducted a retrospective review of patients treated with curative intent from 1980‐2015 at MD Anderson Cancer Center. Results One hundred sixty patients met inclusion criteria, including 8 who were treated with radiotherapy alone. Median follow‐up time was 55 months. The 5‐year overall survival (OS) and disease‐free survival (DFS) rates were 67.0% and 49.0%, respectively. The 10‐year OS and DFS rates were 44.8% and 25.4%, respectively. Factors that portended for poor survival on multivariate analysis were recurrent disease, any solid type histology, epicenter in the sinus cavity, the presence of facial symptoms, or the original disease not treated with surgery. There was no association between surgical margin status or nodal status and survival. Conclusion In this large cohort of patients with sinonasal ACC with extended follow‐up, long‐term survival is better than reported in prior literature. Future research should target patients with adverse risk factors.