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Neutrophil‐to‐lymphocyte ratio as a prognostic indicator in head and neck cancer: A systematic review and meta‐analysis
Author(s) -
Tham Tristan,
Bardash Yonatan,
Herman Saori Wendy,
Costantino Peter David
Publication year - 2018
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.25324
Subject(s) - medicine , meta analysis , oncology , head and neck cancer , neutrophil to lymphocyte ratio , adjuvant therapy , disease , cancer , lymphocyte
Background The purposes of this systematic review and meta‐analysis were to investigate the relationship between the neutrophil‐to‐lymphocyte ratio (NLR) and prognosis in head and neck cancer. Methods A systematic review and meta‐analysis were done to investigate the role of NLR in overall survival (OS), disease‐specific survival (DSS), disease‐free survival (DFS), and progression‐free survival (PFS). Results For qualitative analysis, 33 cohorts with over 10 072 patients were included. For quantitative analysis, 15 studies were included with 5562 patients. The pooled data demonstrated that an elevated NLR significantly predicted poorer OS and DSS. Conclusion An elevated pretreatment NLR is a prognostic marker for head and neck cancer. It represents a simple and easily obtained marker that could be used to stratify groups of high‐risk patients who might benefit from adjuvant therapy.