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Effect of cell‐phone radiofrequency on angiogenesis and cell invasion in human head and neck cancer cells
Author(s) -
Alahmad Yaman M.,
Aljaber Mohammed,
Saleh Alaaeldin I.,
Yalcin Huseyin C.,
Aboulkassim Tahar,
Yasmeen Amber,
Batist Gerald,
Moustafa AlaEddin Al
Publication year - 2018
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.25210
Subject(s) - angiogenesis , cell , cancer cell , chorioallantoic membrane , cancer research , cell growth , cancer , cell culture , biology , pathology , medicine , microbiology and biotechnology , genetics
Background Today, the cell phone is the most widespread technology globally. However, the outcome of cell‐phone radiofrequency on head and neck cancer progression has not yet been explored. Methods The chorioallantoic membrane (CAM) and human head and neck cancer cell lines, FaDu and SCC25, were used to explore the outcome of cell‐phone radiofrequency on angiogenesis, cell invasion, and colony formation of head and neck cancer cells, respectively. Western blot analysis was used to investigate the impact of the cell phone on the regulation of E‐cadherin and Erk1/Erk2 genes. Results Our data revealed that cell‐phone radiofrequency promotes angiogenesis of the CAM. In addition, the cell phone enhances cell invasion and colony formation of human head and neck cancer cells; this is accompanied by a downregulation of E‐cadherin expression. More significantly, we found that the cell phone can activate Erk1/Erk2 in our experimental models. Conclusion Our investigation reveals that cell‐phone radiofrequency could enhance head and neck cancer by stimulating angiogenesis and cell invasion via Erk1/Erk2 activation.