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Esthesioneuroblastoma with distant metastases: Systematic review & meta‐analysis
Author(s) -
Marinelli John P.,
Janus Jeffrey R.,
Van Gompel Jamie J.,
Link Michael J.,
Foote Robert L.,
Lohse Christine M.,
Price Katharine A.,
Chintakuntlawar Ashish V.
Publication year - 2018
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.25209
Subject(s) - medicine , esthesioneuroblastoma , chemotherapy , oncology , radiation therapy , regimen , meta analysis , surgery , overall survival
Background The purpose of this study was to determine the clinical outcomes and review the management strategies for metastatic esthesioneuroblastoma. Methods We conducted a systematic review and meta‐analysis. Results Forty‐eight studies totaling 118 patients met inclusion criteria. Chemotherapy in combination with surgery and/or radiation exhibited the best overall survival when compared to monotherapy and no treatment ( P < .001). However, most patients (66%) received either monotherapy or no therapy. The number and location of metastases among the 3 treatment groups did not significantly differ ( P = .85). Treatment modality remained significantly associated with overall survival on multivariable analysis ( P < .001). Platinum‐based chemotherapy was most commonly utilized but did not provide a survival benefit when compared with all other regimens ( P = .88). Conclusion Distant metastases with esthesioneuroblastoma portend a poor prognosis. Chemotherapy in combination with surgery and/or radiation was associated with improved overall survival. Further research into the optimal systemic therapeutic regimen for patients with distant metastases is critical.