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Pretreatment neurocognitive function and self‐reported symptoms in patients with newly diagnosed head and neck cancer compared with noncancer cohort
Author(s) -
Bernstein Lori J.,
Pond Gregory R.,
Gan Hui K.,
Tirona Kattleya,
Chan Kelvin K.,
Hope Andrew,
Kim John,
Chen Eric X.,
Siu Lillian L.,
Razak Albiruni R. Abdul
Publication year - 2018
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.25198
Subject(s) - medicine , neurocognitive , head and neck cancer , cohort , anxiety , neuropsychology , mood , cancer , cognition , neuropsychological test , depression (economics) , effects of sleep deprivation on cognitive performance , cohort study , neuropsychological assessment , oncology , clinical psychology , psychiatry , economics , macroeconomics
Background Newly diagnosed patients with head and neck cancer may be at risk for impaired neurocognitive function (NCF) due to disease, treatment, and lifestyle factors. Methods Eighty pretreatment patients with head and neck cancer and 40 control patients without cancer completed assessment of NCF and self‐reported cognition, fatigue, and mood. Blood samples to evaluate organ reserves, hormones, and cytokines were collected. Results Patients experienced worse symptoms of cognitive dysfunction, fatigue, and anxiety than controls. In contrast, NCF was equivalent for patients and controls. Using published norms as comparison, groups had similar high rates of impairment in performance (9/80 patients and 3/40 controls scored in the abnormal range). Conclusion Pretreatment patients with head and neck cancer reported cognitive disturbance. The frequency of impaired performance, albeit high, was consistent with the literature demonstrating false‐positive “abnormal” neuropsychological test performance is not uncommon. Inclusion of a noncancer patient control cohort is essential because using solely normative data as a comparison may foster erroneous interpretation.