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Locoregionally advanced oral cavity cancer: A propensity‐score matched analysis on overall survival with emphasis on the impact of adjuvant radiotherapy
Author(s) -
Shin Jacob Y.,
Yoon Ja Kyoung,
Shin Aaron K.,
Diaz Aidnag Z.
Publication year - 2018
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.25185
Subject(s) - medicine , propensity score matching , adjuvant , proportional hazards model , cohort , radiation therapy , oncology , cancer , adjuvant radiotherapy , overall survival , surgery
Abstrac Background The purpose of this study was to determine the impact of adjuvant radiotherapy (RT) in locoregionally advanced oral cavity cancer. Methods Data were extracted from the National Cancer Data Base, of which overall survival (OS) is the only outcome variable available. The chi‐square test and Cox regression models were used. Results A total of 6654 patients were identified. The utilization of adjuvant RT has increased over time. A propensity matched cohort included 3946 patients, exactly one‐half of whom received adjuvant RT. Independent predictors associated with receipt of adjuvant RT included age, Charlson/Deyo comorbidity score, extracapsular extension, surgical margins, and T and N classifications. On multivariable analysis, adjuvant RT remained an independent prognosticator for OS. Conclusion Receipt of adjuvant RT is a prognostic factor associated with improved OS, its utilization has increased over time, and it should be considered for clinically suitable patients who have undergone resection for the disease.