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Association between nasopharyngeal carcinoma and risk of optic neuropathy: A population‐based cohort study
Author(s) -
Fan ChaoYueh,
Jen YeeMin,
Su YuanChih,
Chao HsingLung,
Lin ChunShu,
Huang WenYen,
Lin MiaoJung,
Kao ChiaHung
Publication year - 2018
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.25177
Subject(s) - medicine , nasopharyngeal carcinoma , optic neuropathy , hazard ratio , proportional hazards model , confidence interval , cohort study , oncology , population , cohort , surgery , optic nerve , ophthalmology , radiation therapy , environmental health
Background The purpose of this study was to assess the predictive factors of optic neuropathy among patients with nasopharyngeal carcinoma (NPC). Methods The analysis included 16 297 patients with NPC and 65 187 controls. Each patient with NPC was randomly frequency‐matched with 4 individuals without NPC by age, sex, and index year. Cox proportional hazard models were applied to measure the hazard ratios (HRs) and 95% confidence intervals (CIs) of optic neuropathy development associated with NPC. Results The risk of optic neuropathy was significantly higher in the NPC cohort (adjusted HR [aHR] 3.42; 95% CI 2.85‐4.09; P < .001). Independent risk factors for optic neuropathy among patients with NPC included stroke (aHR 1.7; 95% CI 1.07‐2.7; P = .03) and receipt of chemotherapy (aHR 1.55; 95% CI 1.17‐2.06; P = .002). Conclusion The risk of optic neuropathy was significantly higher in patients with NPC than in the general population.