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Treatment for T3 to T4a laryngeal cancer by open partial horizontal laryngectomies: Prognostic impact of different pathologic tumor subcategories
Author(s) -
Succo Giovanni,
Crosetti Erika,
Bertolin Andy,
Piazza Cesare,
Molteni Gabriele,
Cirillo Stefano,
Petracchini Massimo,
Tascone Martina,
Sprio Andrea Elio,
Berta Giovanni Nicolao,
Peretti Giorgio,
Presutti Livio,
Rizzotto Giuseppe
Publication year - 2018
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.25176
Subject(s) - laryngectomy , medicine , cancer , laryngeal neoplasm , oncology , larynx , general surgery , radiology , surgery
Background The purpose of this retrospective study was to identify subcategories in cT3 to cT4a supraglottic/glottic cancers, describing their different spreading patterns, and local and locoregional recurrence modes. Methods Four hundred eighty‐nine patients who underwent open partial horizontal laryngectomies (OPHLs) were retrospectively classified as: subcategory I (anterior pT3 with normal arytenoid mobility); subcategory II (posterior pT3 with impaired/absent mobility); subcategory III (anterior pT4 with normal mobility); and subcategory IV (posterior pT4 with impaired/absent mobility). Results Five‐year overall survival (OS), disease‐specific survival (DSS), disease‐free survival (DFS), locoregional, local control, freedom from laryngectomy, and laryngectomy‐free survival were significantly better in anterior tumors (subcategories I and III) when compared with the corresponding posterior ones (subcategories II and IV). Conclusion Anterior cT3 tumors are manageable by OPHL, and this approach could also be proposed in the treatment of early anterior cT4aN0. Despite promising results, OPHLs should be considered under investigation in posterior cT3 tumors due to clinical and biological behavior similar to cT4a tumors.