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MR lymphography for sentinel lymph node detection in patients with oral cavity cancer: Preliminary clinical study
Author(s) -
Bae Sohi,
Lee HoJoon,
Nam Woong,
Koh Yoon Woo,
Choi Eun Chang,
Kim Jinna
Publication year - 2018
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.25167
Subject(s) - medicine , lymph , sentinel lymph node , radiology , lymph node , biopsy , occult , cancer , pathology , breast cancer , alternative medicine
Abstract Background The purpose of this study was to evaluate the feasibility of MR lymphography with interstitial injection of a gadolinium‐based contrast agent for identifying sentinel lymph nodes in patients with oral cavity cancer and clinically negative neck. Methods Pretreatment MR lymphography with a differential subsampling with cartesian ordering (DISCO) sequence was performed in 26 patients with resectable oral cavity cancer and clinically negative neck, after peritumoral injection of 1‐mL diluted gadobutrol. The accuracy of sentinel lymph node identification by MR lymphography was assessed and compared with the final histopathological results. Results The MR lymphography consistently visualized the 44 sentinel lymph nodes in all 26 patients. In all but 1 patient with pathologically positive neck, assumed sentinel lymph nodes revealed metastatic involvement. Conclusion Pretreatment MR lymphography is a safe and feasible imaging technique that can help clinicians identify sentinel lymph nodes with a high risk of occult metastases in patients with oral cavity cancer, enabling focused preoperative biopsy in these high‐risk patients.