BRAF wild  papillary thyroid carcinoma has two distinct mRNA expression patterns with different clinical behaviors | Zendy

Kim Hyeung Kyoo | Zendy; Lee Inhwa | Zendy; Lee Jeonghun | Zendy; Chang HangSeok | Zendy; Soh Euy Young | Zendy; Park Il Seok | Zendy; Kim Jin Hwan | Zendy; Rho Young Soo | Zendy; Lee Dong Jin | Zendy

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BRAF wild papillary thyroid carcinoma has two distinct mRNA expression patterns with different clinical behaviors

Author(s) -

Kim Hyeung Kyoo,

Lee Inhwa,

Lee Jeonghun,

Chang HangSeok,

Soh Euy Young,

Park Il Seok,

Kim Jin Hwan,

Rho Young Soo,

Lee Dong Jin

Publication year - 2018

Publication title -

head and neck

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.012

H-Index - 127

eISSN - 1097-0347

pISSN - 1043-3074

DOI - 10.1002/hed.25151

Subject(s) - biology , thyroid carcinoma , gene , thyroid cancer , gene ontology , oncology , papillary thyroid cancer , medicine , cancer research , computational biology , gene expression , cancer , bioinformatics , thyroid , genetics

Using a large set of genomic data from The Cancer Genome Atlas (TCGA), we classified BRAF wild papillary thyroid carcinomas (PTCs) into 2 subtypes with distinct molecular patterns and different clinical behaviors. We also suggested gene signatures (RAS-score) to predict molecular subtypes and clinical behaviors of BRAF wild PTC.

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