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Circulating tumor DNA as a biomarker and liquid biopsy in head and neck squamous cell carcinoma
Author(s) -
Payne Karl,
Spruce Rachel,
Beggs Andrew,
Sharma Neil,
Kong Anthony,
Martin Timothy,
Parmar Satyesh,
Praveen Prav,
Nankivell Paul,
Mehanna Hisham
Publication year - 2018
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.25140
Subject(s) - head and neck squamous cell carcinoma , liquid biopsy , biomarker , head and neck cancer , medicine , head and neck , biopsy , oncology , pathology , cancer , basal cell , cancer research , biology , surgery , genetics
The use of circulating biochemical molecular markers in head and neck cancer holds the promise of improved diagnostics, treatment planning, and posttreatment surveillance. In this review, we provide an introduction for the head and neck surgeon of the basic science, current evidence, and future applications of circulating tumor DNA (ctDNA) as a biomarker and liquid biopsy to detect tumor genetic heterogeneity in patients with head and neck squamous cell carcinoma (HNSCC).