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Quality of head and neck radiotherapy reporting in randomized controlled trials
Author(s) -
Tseng Michelle,
Tan Teng Hwee,
Zheng Huili,
Soon Yu Yang,
Tey Jeremy
Publication year - 2018
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.25133
Subject(s) - medicine , randomized controlled trial , confidence interval , odds ratio , clinical trial , medline , meta analysis , head and neck , head and neck cancer , radiation therapy , physical therapy , surgery , political science , law
Abstract Background The purpose of this clinical review was to determine the quality reporting of radiotherapy (RT) in randomized controlled trials (RCTs) of head and neck cancer and its impact on reporting of the trial primary efficacy and toxicity outcomes. Methods We searched MEDLINE for eligible RCTs published between 1994 and 2015. We assessed the quality of RT reporting and bias in the reporting of trial outcomes using published criteria. Results We found 67 eligible trial reports. There was significant variability in the quality of RT treatment reporting among the included trials. Thirty‐two trials had adequate quality RT reporting. Cooperative group trials were more likely to have adequate quality reporting (odds ratio [OR] 3.02; 95% confidence interval [CI] 1.04‐9.85). The quality of RT reporting did not influence the bias in the reporting of trial outcomes. Conclusion The quality of head and neck RT reporting in RCTs is variable and did not impact on bias in reporting of trial outcomes.