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Polyethylene glycol fusion associated with antioxidants: A new promise in the treatment of traumatic facial paralysis
Author(s) -
Salomone Raquel,
Jácomo Alfredo Luiz,
Nascimento Silvia Bona do,
Lezirovitz Karina,
Hojaij Flávio Carneiro,
Costa Heloisa Juliana Zabeu Rossi,
Bento Ricardo Ferreira
Publication year - 2018
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.25122
Subject(s) - polyethylene glycol , peg ratio , medicine , regeneration (biology) , surgery , chemistry , biology , microbiology and biotechnology , biochemistry , finance , economics
Background Recent studies in invertebrates have taught us that early cell membrane regeneration is determinant for axonal recovery and survival after trauma. Many authors obtained extraordinary results in neural regeneration using polyethylene glycol fusion protocols, which also involved microsutures and antioxidants. Methods Sixty rats were evaluated with functional and histological protocol after facial nerve neurotmesis. Groups A and B had their stumps coapted with microsuture after 24 hours of neurotmesis and groups C and D after 72 hours. In addition to the microstructure, groups B and D used the polyethylene glycol‐fusion protocol for the modulation of the Ca +2 . Results At the sixth week, the latency of group D and duration of group B was lower than groups A and C ( P = .011). The axonal diameter of the groups that used polyethylene glycol‐fusion was higher than those who did not use polyethylene glycol‐fusion ( P ≤ .001). Conclusion Although not providing a functional improvement, polyethylene glycol‐fusion slowed down demyelination.