z-logo
Premium
Sarcomas of the sinonasal tract
Author(s) -
Kauke Martin,
Safi AliFarid,
Grandoch Andrea,
Nickenig HansJoachim,
Zöller Joachim,
Kreppel Matthias
Publication year - 2018
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.25108
Subject(s) - medicine , overall survival , retrospective cohort study , sarcoma , cohort , neoplasm , multimodal therapy , disease , oncology , surgery , pathology
Background Sinonasal sarcomas are rare and heterogeneous in nature. Continuously collecting data influencing the prognosis is fundamental for optimizing therapeutic assessment of this highly destructive neoplasm. Methods We conducted a single‐institution retrospective cohort study considering 27 patients with sinonasal sarcoma. Results The overall survival (OS) rates for 1 year and 5 years were calculated as 74% and 36%, respectively. Extent of the primary tumor ( P  = .010), nodal spread ( P  = .009), and age ( P  = .004) significantly reduced the OS. Disease‐free survival (DFS) was significantly reduced by age ( P  = .003), extent of the primary ( P  = .006), nodal ( P  = .004), and hematogenous ( P  = .048) spread. Multimodal therapy including surgery improved the OS and DFS rates ( P  < .05). Conclusion Prognosis is poor due to late disease recognition. However, multimodal therapeutic regimens, including surgery, may improve the outcome.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here