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Effects of excessive fibrin deposit and polylactide adhesion barrier on wound healing in thyroidectomy murine wound model
Author(s) -
Lim YunSung,
Kim HeeBok,
Park Joo Hyun,
Cho Chang Gun,
Park SeokWon,
Lee Jae Suk,
Kim Eo Jin,
Kwon Seong Keun
Publication year - 2018
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.25096
Subject(s) - fibrin , wound healing , hemostasis , inflammation , adhesion , chemistry , deposition (geology) , medicine , pathology , surgery , immunology , biology , paleontology , organic chemistry , sediment
Background We hypothesize that excessive fibrin formation and inflammation induced by antiadhesive material, SurgiWrap (SW), would have an adverse effect on wound healing. It was evaluated by a thyroidectomy murine wound model. Methods Excessive fibrin formation was induced by isthmectomy without hemostasis. Rats were allocated into isthmectomy with SurgiWrap (I+SW+), I+SW‐, I‐SW+, I‐SW‐, and isthmectomy after electrocautery for hemostasis (I+C+SW‐). The SWs were placed on the superficial and visceral layers for gross and microscopic evaluation. Results Microscopic examination showed collagen deposition occurred in the I‐SW‐ sham group and at a higher level in I+C+SW‐. The collagen deposition decreased in groups without SW with time but increased in groups with SW. Use of SW produced more inflammation and more collagen deposition. The I+SW + group developed the largest area of collagen deposition at 4 weeks and more collagen deposition than the I‐SW + group. Conclusion The SW induced more collagen deposition increasing with time. The collagen deposition produced by SW was worsened by excessive fibrin formation and inflammation.