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Modified combination of platelet count and neutrophil “to” lymphocyte ratio as a prognostic factor in patients with advanced head and neck cancer
Author(s) -
Nakayama Masahiro,
Gosho Masahiko,
Hirose Yuki,
Nishimura Bungo,
Tanaka Shuho,
Tabuchi Keiji,
Okubo Hideki,
Wada Tetsuro,
Hara Akira
Publication year - 2018
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.25085
Subject(s) - medicine , neutrophil to lymphocyte ratio , absolute neutrophil count , mean platelet volume , head and neck cancer , platelet , oncology , gastroenterology , lymphocyte , cancer , neutropenia , toxicity
Background We evaluated the prognostic potential of the combination of platelet count and neutrophil to lymphocyte ratio (COP‐NLR) in patients with advanced head and neck cancer. Methods We proposed a modified COP‐NLR scoring system defined as follows: score 0 (platelet count level <300 × 10 9 /L and NLR <3); score 1 (platelet count level ≥300 × 10 9 /L and NLR <3); and score 2 (NLR ≥3). We assessed whether the modified scoring system had better performance as an indicator of prognosis than the existing COP‐NLR scoring system (original and 4‐group scores). Results A total of 248 patients were enrolled. The Akaike Information Criterion value with the modified COP‐NLR score was the smallest among the 3 models. The 3‐year survival rates according to the modified COP‐NLR scores of 0, 1, and 2 were 80.6%, 59.9%, and 23.8%, respectively. Conclusion The modified COP‐NLR score is a useful prognostic marker in patients with advanced head and neck cancer.