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Risk analysis of malignant potential of oral verrucous hyperplasia: A follow‐up study of 269 patients and copy number variation analysis
Author(s) -
Wu MingHeng,
Luo JiDung,
Wang WenChang,
Chang TzuHao,
Hwang WeiLun,
Lee KuenHaur,
Liu ShyunYeu,
Yang JungWu,
Chiou ChangTa,
Chang ChiHua,
Chiang WeiFan
Publication year - 2018
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.25076
Subject(s) - medicine , oral submucous fibrosis , verrucous carcinoma , hyperplasia , proportional hazards model , malignant transformation , oncology , dermatology , pathology , carcinoma
Background Oral verrucous hyperplasia is commonly observed in the oral cavity of betel quid chewers and is a potential malignant disorder. However, the prognostic factors and genetic alterations of oral verrucous hyperplasia are unclear. Methods We calculate the survival rate and prognostic factors using a Kaplan‐Meier analysis and Cox proportional hazards regression model. Copy number variations were analyzed using a single‐nucleotide polymorphism (SNP) array. Results The 5‐year disease‐free and cancer‐free survival rates of patients with oral verrucous hyperplasia were approximately 40% and 70%, respectively. Heavy betel quid chewing, advanced oral submucous fibrosis, and nonbuccal and nontongue lesions were risk factors for malignant transformation, whereas dysplasia did not affect outcomes. The gene amplification of CTTN, FOLR3, ORAOV1, PPFIA1 , and RNF121 were associated with the poor prognosis of oral verrucous hyperplasia. Conclusion Heavy betel quid chewing, advanced oral submucous fibrosis, and nonbuccal and nontongue lesions are high‐risk factors of patients with oral verrucous hyperplasia. The 5‐copy number variation‐associated genes could be used for early diagnosis and predicting the prognosis.