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Evaluation of treatment outcomes in patients with supraglottic laryngeal cancer in Ontario, Canada: A population‐based study
Author(s) -
Hall Stephen F.,
Griffiths Rebecca J.
Publication year - 2018
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.25073
Subject(s) - medicine , laryngectomy , radiation therapy , hazard ratio , carcinoma , cancer , head and neck cancer , surgery , glottis , proportional hazards model , population , retrospective cohort study , oncology , larynx , confidence interval , environmental health
Abstract Background Supraglottic laryngeal carcinoma has an entirely different etiology, clinical presentation, and prognosis compared to glottis cancer but the only evidence for the use of concurrent chemotherapy with radiotherapy (CRT) is the 5.4% 5‐year improvement in overall survival (OS) for the combined laryngeal site. Method We conducted a retrospective population‐based study using administrative data to compare OS, disease‐specific survival (DSS), laryngectomy‐free survival, and laryngoesophageal dysfunction‐free survival over time and by treatment for all patients with supraglottic laryngeal carcinoma diagnosed between January 1, 1990, and December 31, 2014, in Ontario, Canada. Results There was no improvement over time in OS (hazard ratio [HR] 1.006; P = .90), DSS (HR 1.031; P = .65), or laryngoesophageal dysfunction‐free survival ( P = .39). The patients selected for CRT had similar OS (HR 1.04; P = .66), laryngectomy‐free survival (HR 0.95; P = .23), and laryngoesophageal dysfunction‐free survival ( P = .79) compared with patients undergoing radiotherapy. Conclusion The addition of CRT by head and neck oncologists in Ontario, Canada, did not improve outcomes for the “real world” patients with supraglottic laryngeal carcinoma.