Premium
Effect of preoperative immunonutrition on postoperative short‐term outcomes of patients with head and neck squamous cell carcinoma
Author(s) -
Aeberhard Carla,
Mayer Catherine,
Meyer Simone,
Mueller Simon Andreas,
Schuetz Philipp,
Stanga Zeno,
Giger Roland
Publication year - 2018
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.25072
Subject(s) - medicine , perioperative , odds ratio , head and neck squamous cell carcinoma , head and neck cancer , multivariate analysis , basal cell , surgery , confidence interval , head and neck , carcinoma , radiation therapy
Background Patients with head and neck squamous cell carcinoma (HNSCC) often acquire an impaired nutritional status resulting in compromised outcomes. Perioperative immunonutrition may have a positive effect on outcomes after elective surgery. Methods Short‐term outcomes before and after implementation of preoperative immunonutrition were retrospectively assessed. Regression models adjusted for outcome predictors were used to compare the length of stay (LOS) in the hospital, local infections, and general complications. Results Four hundred eleven patients were included (control group = 209 and the intervention group = 202). With immunonutrition, hospital LOS was significantly lower (median 6 vs 8 days; adjusted mean difference of −5.65 days; P < .001) and local infections were significantly reduced (7.4% vs 15.3%; adjusted odds ratio [OR] 0.30; P = .006). Subgroup analysis showed more pronounced effects in patients with previous radiotherapy and extensive surgery. Conclusion Patients receiving preoperative immunonutrition had a shorter hospital LOS and a lower rate for wound infections and local complications. These effects remained robust after a multivariate adjustment.