Premium
Predictors of clinical‐pathologic stage discrepancy in oral cavity squamous cell carcinoma: A National Cancer Database study
Author(s) -
Kılıç Sarah S.,
Kılıç Suat,
Crippen Meghan M.,
Varughese Denny,
Eloy Jean Anderson,
Baredes Soly,
Mahmoud Omar M.,
Park Richard Chan Woo
Publication year - 2018
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.25065
Subject(s) - stage (stratigraphy) , oral cavity , medicine , cancer , basal cell , t stage , logistic regression , multivariate analysis , database , carcinoma , oncology , radiology , biology , paleontology , orthodontics , computer science
Abstract Background Few studies have examined the frequency and survival implications of clinicopathologic stage discrepancy in oral cavity squamous cell carcinoma (SCC). Methods Oral cavity SCC cases with full pathologic staging information were identified in the National Cancer Database (NCDB). Clinical and pathologic stages were compared. Multivariate logistic regressions were performed to identify factors associated with stage discrepancy. Results There were 9110 cases identified, of which 67.3% of the cases were stage concordant, 19.9% were upstaged, and 12.8% were downstaged. The N classification discordance (28.5%) was more common than T classification discordance (27.6%). In cases of T classification discordance, downstaging is more common than upstaging (15.4% vs 12.1% of cases), but in cases of N classification discordance, the reverse is true; upstaging is much more common than downstaging (20.1 vs 8.4% of cases). Conclusion Clinicopathologic stage discrepancy in oral cavity SCC is a common phenomenon that is associated with a number of clinical factors and has survival implications.