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Endoscopic endonasal approach for sinonasal and anterior skull base malignancies in the elderly
Author(s) -
Lepera Davide,
Leone Federico,
Volpi Luca,
Bignami Maurizio,
Karligkiotis Apostolos,
Lambertoni Alessia,
Pistochini Andrea,
Accorona Remo,
Nicolai Piero,
Castelnuovo Paolo
Publication year - 2018
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.25045
Subject(s) - medicine , esthesioneuroblastoma , contraindication , surgery , multivariate analysis , univariate analysis , stage (stratigraphy) , skull , retrospective cohort study , radiation therapy , paleontology , alternative medicine , biology , pathology
Background The purpose of this study was to report the outcomes of endoscopic transnasal resection for sinonasal and anterior skull‐base cancers in elderly patients. Methods A retrospective review was performed. The patients were divided into 2 groups, <70 years old and ≥70 years old and compared by univariate analysis. Prognostic factors were evaluated with a multivariate analysis. Survival rates were also calculated. Results Two hundred three elderly patients and 397 younger patients were enrolled in this study. The elderly patients reported lower survival rates than the younger patients. When melanoma and esthesioneuroblastoma were censored, the disease‐specific survival (DSS) and recurrence‐free survival (RFS) were similar. Complication rates were 17.5% without any statistical significance between the groups. Multivariate analysis revealed that histology, stage, surgical margins, and surgical approaches were independent predictors of survival in elderly patients. Conclusion The endoscopic transnasal approach reported low mortality and morbidity rates also in geriatric patients, and age itself is not to be considered as a contraindication.