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Combined human papillomavirus typing and TP53 mutation analysis in distinguishing second primary tumors from lung metastases in patients with head and neck squamous cell carcinoma
Author(s) -
Daher Tamas,
Tur Mehmet Kemal,
Brobeil Alexander,
Etschmann Benjamin,
Witte Biruta,
EngenhartCabillic Rita,
Krombach Gabriele,
Blau Wolfgang,
Grimminger Friedrich,
Seeger Werner,
Klussmann Jens Peter,
Bräuninger Andreas,
Gattenlöhner Stefan
Publication year - 2018
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.25041
Subject(s) - head and neck squamous cell carcinoma , medicine , lung , oncology , lung cancer , carcinoma , typing , head and neck cancer , human papillomavirus , cancer research , pathology , cancer , biology , genetics
Background In head and neck squamous cell carcinoma (HNSCC), the occurrence of concurrent lung malignancies poses a significant diagnostic challenge because metastatic HNSCC is difficult to discern from second primary lung squamous cell carcinoma (SCC). However, this differentiation is crucial because the recommended treatments for metastatic HNSCC and second primary lung SCC differ profoundly. Methods We analyzed the origin of lung tumors in 32 patients with HNSCC using human papillomavirus (HPV) typing and targeted next generation sequencing of all coding exons of tumor protein 53 ( TP53 ). Results Lung tumors were clearly identified as HNSCC metastases or second primary tumors in 29 patients, thus revealing that 16 patients had received incorrect diagnoses based on clinical and morphological data alone. Conclusion The HPV typing and mutation analysis of all TP53 coding exons is a valuable diagnostic tool in patients with HNSCC and concurrent lung SCC, which can help to ensure that patients receive the most suitable treatment.