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Prognostic value of tumor volume in patients with head and neck squamous cell carcinoma treated with primary surgery
Author(s) -
Dejaco Daniel,
Steinbichler Teresa,
Schartinger Volker H.,
Fischer Natalie,
Anegg Maria,
Dudas Jozsef,
Posch Andrea,
Widmann Gerlig,
Riechelmann Herbert
Publication year - 2018
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.25040
Subject(s) - medicine , basal cell , head and neck , head and neck squamous cell carcinoma , primary tumor , carcinoma , volume (thermodynamics) , oncology , head and neck cancer , surgery , radiation therapy , cancer , metastasis , physics , quantum mechanics
Background Tumor volume in head and neck squamous cell carcinoma (HNSCC) was mainly measured in nonsurgically treated patients. We analyzed the influence of tumor volume on complete response (CR), overall survival (OS), and clear surgical margins also in primarily surgically treated patients. Methods In contrast‐enhanced CTs, the tumor volumes of patients with incident HNSCC were measured. Results The tumor volumes of 259 patients were measured, of which 125 patients (48%) underwent primary surgery and 102 patients (84%) had clear margins. The tumor volume was not an independent factor for CR at the primary tumor site. Risk of death increased by 1.4% per mL of tumor volume (95% confidence interval [CI] 0.8%‐2.0%; P < .001). The OS was better in patients treated with primary surgery, if the tumor volume was ≤12 mL ( P < .001). Risk of involved margins increased by 4.5% per mL of tumor volume (95% CI 0.9%‐8.3%; P = .003). The predicted probability of clear margins was ≥80% in tumor volumes ≤ 16 mL. Conclusion The tumor volume had an impact on CR, OS, and clear margins. The tumor volume may also aid in selecting HNSCC treatment.