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Submandibular gland cancer: Specific features and treatment considerations
Author(s) -
Aro Katri,
Tarkkanen Jussi,
Saat Riste,
Saarilahti Kauko,
Mäkitie Antti,
Atula Timo
Publication year - 2018
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.24981
Subject(s) - submandibular gland , occult , medicine , adenoid cystic carcinoma , cancer , neck dissection , malignancy , salivary gland , metastasis , pathology , parotid gland , salivary gland cancer , oncology , carcinoma , alternative medicine
Background In the absence of unified treatment protocol, we evaluated the management and outcomes of submandibular gland cancers in an unselected patient series. Methods We included all patients with resected submandibular gland cancer treated at the Helsinki University Hospital from 2000 to 2010 with a 5‐year minimum follow‐up. Results Twenty‐five patients with cancer represented 30% of submandibular gland neoplasms, and most were adenoid cystic carcinomas (ACCs; 56%). At presentation, 3 patients showed clinical signs of probable malignancy. Of 22 neck dissection specimens, 5 patients (20%) had metastases with an occult metastasis rate of 4%. Cancer recurred in 11 patients (44%), of which 7 (28%) were only at a distant site. The 5‐year disease‐specific survival (DSS) and overall survival (OS) rates were 76%, and disease‐free survival (DFS) was 68%. Conclusion Most tumors were ACCs differing from the histological pattern of parotid gland cancers. Occult metastases were rare. The rarity of submandibular gland cancer, its variable histological pattern, and varying biological behavior warrant centralized management.