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Genomic profiling of intestinal‐type sinonasal adenocarcinoma reveals subgroups of patients with distinct clinical outcomes
Author(s) -
LópezHernández Alejandro,
PérezEscuredo Jhudit,
Vivanco Blanca,
GarcíaInclán Cristina,
PotesAres Sira,
Cabal Virginia N.,
Riobello Cristina,
Costales María,
López Fernando,
Llorente José Luis,
Hermsen Mario A.
Publication year - 2018
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.24941
Subject(s) - comparative genomic hybridization , pathological , adenocarcinoma , disease , biology , medicine , gene , bioinformatics , genetics , genome , cancer
Background Patients with intestinal‐type sinonasal adenocarcinoma (ITAC) have an unfavorable prognosis and new therapeutic approaches are needed to improve clinical management. Methods Genetic analysis of 96 ITACs was performed by microarray comparative genomic hybridization and immunohistochemistry and correlated to previously obtained mutation, methylation, and protein expression data, and with pathological characteristics and clinical outcome. Results Seven copy number alterations (CNAs) were significantly associated with unfavorable clinical outcome: gains at 1q22‐23, 3q28‐29, 6p22, and 13q31‐33, and losses at 4p15‐16, 4q32‐35, and 10q24. Unsupervised cluster analysis resulted in 5 subgroups of ITAC with significantly distinct genetic signatures and clinical outcomes, independently of disease stage or histological subtype. Conclusion These data may guide studies to identify driver genes and signaling pathways involved in ITAC. In addition, the subclassification of genetic subgroups of patients with distinct clinical behavior can aid therapeutic decision making and may ultimately lead to personalized therapy with targeted inhibitors.

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