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Importance of lymph node ratio for locoregional recurrence of squamous cell carcinoma of the buccal mucosa
Author(s) -
Safi AliFarid,
Grandoch Andrea,
Nickenig HansJoachim,
Zöller Joachim E.,
Kreppel Matthias
Publication year - 2017
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.24922
Subject(s) - medicine , lymph node , hazard ratio , multivariate analysis , univariate analysis , malignancy , buccal administration , carcinoma , oncology , gastroenterology , confidence interval , pharmacology
Background There is no published study on the influence of lymph node ratio on locoregional recurrence of squamous cell carcinoma (SCC) of the buccal mucosa. Therefore, we focused in our study on this specific anatomic subsite. Methods We conducted a retrospective chart review of 95 patients from 2003‐2013 with treatment‐naive SCC of the buccal mucosa. Exclusion criteria were neoadjuvant chemoradiotherapy, perioperative death, N3 disease, unresectable disease, synchronous malignancy, and follow‐up <3 months. Statistical analysis was performed using univariate and multivariate analysis. Results Significant correlations were found between locoregional recurrence and pathologic N classification ( P < .001), grading ( P = .001), and lymph node ratio ( P < .001). Multivariate analysis indicated lymph node ratio as an independent risk factor for locoregional recurrence ( P = .002). A cutoff value under 7% led to a 10.383‐fold higher risk of incurring a locoregional recurrence. Conclusion Lymph node ratio is a useful parameter to stratify the risk of locoregional recurrence in patients with SCC of the buccal mucosa.