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Association between radioiodine treatment for thyroid cancer and risk of stroke
Author(s) -
Lin ChunYi,
Lin ChengLi,
Lo YiChen,
Kao ChiaHung
Publication year - 2017
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.24903
Subject(s) - medicine , thyroid cancer , confidence interval , stroke (engine) , propensity score matching , incidence (geometry) , cumulative incidence , thyroid , oncology , cohort , mechanical engineering , physics , optics , engineering
Background The purpose of this study was to evaluate the association between radioiodine (I‐131) therapy for thyroid cancer and the risk of stroke in Taiwan. Methods A total of 10 104 of the patients aged 20 years or older, who were newly diagnosed with thyroid cancer during 2000‐2010, were recruited and classified into 2 cohorts according to whether they received I‐131 therapy through 1:1 propensity score matching. The cumulative Kaplan‐Meier curves for the incidence of stroke in the 2 cohorts were compared using the log‐rank test. Results After adjustment for age, sex, and comorbidities, the I‐131 therapy group showed no significantly higher risk of ischemic stroke (adjusted HR [aHR] = 1.05; 95% confidence interval [CI] = 0.82‐1.34) or hemorrhagic stroke (aHR = 1.06; 95% CI = 0.58‐1.93) than did the non‐I‐131 therapy group. Conclusion The I‐131 treatment for thyroid cancer did not increase the risk of stroke during 10‐year follow‐up.