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Prognostic significance of E‐cadherin and β‐catenin expression in HPV‐negative oropharyngeal squamous cell carcinomas
Author(s) -
GarcíaPedrero Juana M.,
GarcíaCabo Patricia,
Ángeles Villaronga M.,
HermidaPrado Francisco,
GrandaDíaz Rocío,
Allonca Eva,
Rodrigo Juan P.
Publication year - 2017
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.24897
Subject(s) - catenin , cadherin , tissue microarray , immunohistochemistry , medicine , oncology , pathology , cell , biology , wnt signaling pathway , gene , biochemistry , genetics
Background The purpose of this work was to investigate the prognostic significance of E‐cadherin and β‐catenin expression in surgically treated human papillomavirus (HPV)‐negative patients with oropharyngeal squamous cell carcinoma (SCC). Methods Consecutive patients with oropharyngeal SCC who underwent surgical treatment between 1990 and 2009 were retrospectively collected. Immunohistochemical analysis of E‐cadherin and β‐catenin expression was performed on tissue microarrays. Results E‐cadherin and β‐catenin expression was evaluable in 232 cases. Low membranous E‐cadherin, low membranous β‐catenin expression, and nuclear β‐catenin expression were associated with a poorer disease‐specific and overall survival, although the differences were only significant for β‐catenin membranous expression ( P = .024 and P = .016, respectively). In multivariate analysis, nodal metastasis and low membranous β‐catenin expression were significant independent predictors of reduced disease‐specific and overall survival. Conclusion Low membranous β‐catenin expression is a significant independent predictor of both reduced disease‐specific and overall survival in patients with HPV‐negative oropharyngeal SCC.