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Size of thyroid carcinoma by histotype and variants: A population‐based study in a mildly iodine‐deficient area
Author(s) -
Marina Michela,
Ceda Gian Paolo,
Corcione Luigi,
Sgargi Paolo,
Michiara Maria,
Silini Enrico Maria,
Ceresini Graziano
Publication year - 2017
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.24877
Subject(s) - thyroid cancer , medicine , thyroid carcinoma , thyroid , cancer , population , pathology , carcinoma , cancer registry , odds ratio , pathological , oncology , environmental health
Background Data relating the size of thyroid cancer with histological types and variants are scarce. Methods All incident thyroid cancer diagnosed between 2003 and 2012 in a mildly iodine‐deficient area were derived from a population‐based tumor registry. Undifferentiated/anaplastic thyroid cancer and incidental cases were excluded. Major diameter of thyroid cancer, as assessed by pathological examination, was stratified in classes: ≤10 mm; 11‐20 mm; 21‐40 mm; and >40 mm. For each class, absolute and relative frequencies of histological types were calculated. Results Tumors >20 mm were more frequent among follicular thyroid carcinoma (FTC) and Hürthle cell carcinoma than in other histotypes, with median size of 22.50 mm (95% confidence interval [CI] 16.71‐28.29) and 25.00 mm (95% CI 17.04‐32.96) in FTC and Hürthle cell carcinoma, respectively. Odds ratio for tumors >20 mm was significant for FTC and Hürthle cell carcinoma only ( P < .0001). Conclusion Among the histotypes and variants of differentiated thyroid cancer, FTC and Hürthle cell carcinoma are characterized by the largest size.