Premium
Outcomes for olfactory neuroblastoma treated with induction chemotherapy
Author(s) -
Su Shirley Y.,
Bell Diana,
Ferrarotto Renata,
Phan Jack,
Roberts Dianna,
Kupferman Michael E.,
Frank Steven J.,
Fuller C. David,
Gunn G. Brandon,
Kies Merrill S.,
Glisson Bonnie S.,
Hanna Ehab Y.
Publication year - 2017
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.24822
Subject(s) - medicine , induction chemotherapy , etoposide , chemotherapy , esthesioneuroblastoma , cisplatin , neuroblastoma , oncology , surgery , overall survival , radiation therapy , biology , genetics , cell culture
Background Oncologic outcomes for induction chemotherapy and its role in patients with advanced olfactory neuroblastoma (ONB) remain unclear. Methods A retrospective review of 15 consecutive patients with extensive local invasion and/or nodal disease treated with induction chemotherapy with curative intent followed by definitive local therapy. Results The majority of patients were treated with cisplatin and etoposide. The response to chemotherapy was 68% (10/15). Response was 78% (7/9) in the high Hyams high‐grade group and 50% (3/6) in the Hyams low‐grade group. Seven patients had complete response (CR) and 3 patients were able to avoid orbital exenteration. The 5‐year disease‐free survival (DFS) and overall survival (OS) were 71% and 78%, respectively, with a trend toward improved survival in patients with CR. Conclusion ONB is a chemosensitive tumor and induction chemotherapy is an acceptable strategy for aggressive and locoregional advanced disease. Hyams grade may predict chemosensitivity and CR may be associated with improved survival.