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Characteristics and prognosis of glomangiopericytomas: A systematic review
Author(s) -
Park Eun Su,
Kim Jiyoung,
Jun SunYoung
Publication year - 2017
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.24818
Subject(s) - immunostaining , medicine , radiation therapy , cd34 , chemotherapy , multivariate analysis , oncology , overall survival , immunohistochemistry , metastasis , gastroenterology , pathology , cancer , biology , stem cell , genetics
Background Glomangiopericytoma belongs to the category of borderline/low‐malignant‐potential tumors of the sinonasal tract, but no studies about prognosis have been reported. Methods To define the characteristics of glomangiopericytoma and to identify its prognostic factors, a systematic review was performed. A total of 337 cases of glomangiopericytomas were analyzed. Results Patients with glomangiopericytoma demonstrating resection margin involvement and receiving radiotherapy/chemotherapy had a significantly worse disease‐free survival time ( P = .014 and .006, respectively). Patients with glomangiopericytoma had a tendency toward longer overall survival when they were diagnosed at a younger age (≤60 years; P = .001), did not demonstrate marginal involvement ( P = .032), recurrence/metastasis ( P = .002), or radiotherapy/chemotherapy ( P = .010), and had a right‐sided tumor ( P < .001), actin‐immunopositivity ( P < .001), and CD34‐/BCL2‐immunonegativities ( P = .002 and .019, respectively). By multivariate analysis, actin ( P < .001) and CD34 ( P = .002) immunostaining were significantly related to the overall survival of patients with glomangiopericytoma. Conclusion Actin and CD34 immunostaining could be used as independent prognostic indicators of glomangiopericytomas.