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Transoral laser microsurgery for treatment for hypopharyngeal cancer in 211 patients
Author(s) -
Weiss Bernhard G.,
Ihler Friedrich,
Wolff Hendrik A.,
Schneider Simon,
Canis Martin,
Steiner Wolfgang,
Welz Christian
Publication year - 2017
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.24814
Subject(s) - transoral laser microsurgery , medicine , neck dissection , microsurgery , stage (stratigraphy) , basal cell , surgery , dissection (medical) , hypopharyngeal cancer , radiation therapy , cancer , head and neck cancer , paleontology , biology
Background The oncologic and functional outcome of transoral laser microsurgery (TLM) for primary treatment of hypopharyngeal cancer was examined in a multimodal treatment concept. Methods Two hundred eleven patients with squamous cell carcinoma (SCC) of the hypopharynx (pT1‐4a, pN0‐2, M0) were treated by TLM +/− neck dissection (88%) +/− (chemo)radiotherapy ([C]RT; 51%). The majority of cases were advanced stages III and IVa (85%). Results The 5‐year Kaplan‐Meier estimates for local control after TLM were pT category‐related 88.1%, 74.8%, 77.3%, and 61.8% for pT1‐4a tumors. The 5‐year estimates of overall survival (OS), disease‐specific survival (DSS), and recurrence‐free survival (RFS) for early stages I and II were 68.2%, 96.7%, and 74.6%, respectively; for stage III they were 65.9%, 83.8%, and 56.4%, respectively; and the rates for stage IVa were 44.5%, 60.7%, and 50.3%, respectively. Overall, 95.7% of the patients maintained regular oral nutrition without feeding tube dependency. Conclusion Primary TLM in multimodal concepts of treatment (+/− neck dissection, +/− [C]RT) offers favorable oncologic results as compared with other therapeutic regimes.