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Multiple single nucleotide polymorphism analysis and association of specific genotypes in FHIT, SAMD4A, and ANKRD17 in Indian patients with oral cancer
Author(s) -
D'Souza Wendy,
Pradhan Sultan,
Saranath Dhananjaya
Publication year - 2017
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.24798
Subject(s) - odds ratio , single nucleotide polymorphism , genotype , medicine , confidence interval , allele , gastroenterology , cancer , snp , cohort , oncology , genetics , biology , gene
Background Oral cancer has a high incidence primarily because of tobacco chewing habits. However, a small proportion of habitués develop oral cancer, implying a role for genomic variants in its susceptibility. Methods Thirteen single nucleotide polymorphisms (SNPs) in an Indian cohort comprising patients with oral cancer (n = 500) and healthy controls (n = 500) were genotyped using allelic discrimination real‐time polymerase chain reaction (PCR). Results Prevalence of SNPs rs11130760, rs1957358, rs2306058, rs4883543, rs12637722, rs1457115, rs2353292, rs709821, rs2194861, rs4789378, rs3827538, rs2667552, and rs2886093 was determined in the Indian cohort. A significant association of rs11130760 GG (odds ratio [OR] 1.41; 95% confidence interval [CI] 1.08‐1.84) and rs1957358 TT (OR 1.44; 95% CI 1.10‐1.90) indicated increased risk; whereas rs1957358 TC (OR 0.67; 95% CI 0.53‐0.87) and rs2306058 CT (OR 0.72; 95% CI 0.56‐0.93) reflected decreased risk. The SNP rs11130760 wild‐type (WT) allele G indicated an increased risk for oral cancer (OR 1.38; 95% CI 1.09‐1.73), whereas SNP allele T indicated a decreased risk (OR 0.73; 95% CI 0.58‐0.92) for oral cancer. Conclusion Our study identified SNPs with susceptibility to oral cancer in high‐risk populations.