Premium
Relationship between iodine levels and papillary thyroid carcinoma: A systematic review and meta‐analysis
Author(s) -
Lee JoonHyop,
Hwang Yunji,
Song RaYeong,
Yi Jin Wook,
Yu Hyeong Won,
Kim Sujin,
Chai Young Jun,
Choi June Young,
Lee Kyu Eun,
Park Sue K.
Publication year - 2017
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.24797
Subject(s) - odds ratio , iodine , medicine , meta analysis , confidence interval , cochrane library , thyroid carcinoma , thyroid cancer , papillary thyroid cancer , thyroid , oncology , chemistry , organic chemistry
Abstract Background Iodine excess has been suggested as an exogenous risk factor of papillary thyroid cancer (PTC). We performed a systematic review and meta‐analysis to assess the relationship between iodine exposure measured in various forms and PTC prevalence. Methods We searched MEDLINE, Embase, and the Cochrane Library for case‐control studies on iodine and PTC published up to December 2015. Exposure to iodine was compared between PTC and control groups. Results From the 16 selected studies, the odds ratio (OR) for the overall effect size between high iodine exposure and PTC risk was 1.418 (95% confidence interval [CI] 1.054‐1.909). Based on 7 studies conducted in high iodinated regions, a positive association between iodine exposure and PTC was observed (OR 2.200; 95% CI 1.389‐3.483). Conclusion This study demonstrated a higher exposure to iodine in patients with PTC compared with controls, especially for patients from high iodinated regions.