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Changing trends in the management of the neck in oropharyngeal squamous cell carcinoma
Author(s) -
Jouhi Lauri,
Atula Timo,
Saarilahti Kauko,
Hagström Jaana,
Haglund Caj,
Mohamed Hesham,
Mäkitie Antti,
KeskiSäntti Harri
Publication year - 2017
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.24781
Subject(s) - medicine , incidence (geometry) , chemoradiotherapy , radiation therapy , lymph node metastasis , basal cell , surgery , oncology , metastasis , cancer , physics , optics
Background Treatment for oropharyngeal squamous cell carcinoma (SCC) has changed toward a more oncologic approach. We evaluated treatment of the neck, the incidence of regional recurrences, and factors associated with regional recurrence during the treatment approach transition period in patients with regional lymph node metastasis. Methods All patients with oropharyngeal SCC diagnosed at the Helsinki University Hospital during 2000‐2009 were analyzed for clinicopathological factors, treatment, p16 expression, and regional recurrence. Results Altogether, 169 patients had a complete response, and among them regional recurrence occurred in 5 patients (4.7%) treated with surgery ± radiotherapy (RT) or chemoradiotherapy (CRT) and in 2 patients (3.2%) treated with RT or CRT ± surgery. All these 7 patients had N2b disease or higher, and 5 of them had regional recurrence in the contralateral side of the neck. Conclusion The incidence of regional recurrence was low, and remained unchanged despite the increased use of RT or CRT ± surgery. Treatment and follow‐up of the contralateral neck warrants special attention in patients with advanced neck disease (≥N2b).