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Implication for second primary cancer from visible oral and oropharyngeal premalignant lesions in betel‐nut chewing related oral cancer
Author(s) -
Liu ShyunYu,
Feng IJung,
Wu YuWei,
Chen ChingYuan,
Hsiung ChaoNan,
Chang HsuehWei,
Lin CheYi,
Chang MinTe,
Yu HsiChien,
Lee ShengYang,
Yen ChingYu
Publication year - 2017
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.24777
Subject(s) - medicine , betel , leukoplakia , cancer , oral leukoplakia , incidence (geometry) , areca , dermatology , gastroenterology , dentistry , nut , physics , structural engineering , optics , engineering
Background Visible oral and oropharyngeal premalignant lesions may be used to monitor for a second primary oral cancer. To control for bias, we focused on the visible oral and oropharyngeal premalignant lesions of patients with oral cancer with a positive betel‐nut chewing habit. Visible oral and oropharyngeal premalignant lesions that can predict second primary oral cancers were studied. Methods Nine hundred ninety‐seven patients with positive betel‐nut chewing habits and oral cancer were enrolled in this retrospective cohort study. We analyzed the relevance of their visible oral and oropharyngeal premalignant lesion incidence and relative clinicopathological variables to the development of a second primary oral cancer. Results Second primary oral cancer risk was significantly higher in patients with positive visible oral and oropharyngeal premalignant lesions ( P < .0001), especially in younger patients ( P = .0023; ≤40 years: adjusted odds ratio [OR] 2.66; 40‐60 years: adjusted OR 2.61). The heterogeneous leukoplakia was (adjusted OR 2.17) higher than homogeneous leukoplakia. Conclusion The predictive value and practicality of visible oral and oropharyngeal premalignant lesions make it a potentially valuable marker in follow‐ups of patients with a positive betel‐nut chewing habit with oral cancer, especially young patients with heterogeneous leukoplakia.