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Systematic review and meta‐analysis of venous thromboembolism in otolaryngology–head and neck surgery
Author(s) -
Moubayed Sami P.,
Eskander Antoine,
Mourad Moustafa W.,
Most Sam P.
Publication year - 2017
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.24758
Subject(s) - medicine , otorhinolaryngology , chemoprophylaxis , incidence (geometry) , pulmonary embolism , venous thrombosis , odds ratio , surgery , head and neck cancer , meta analysis , thrombosis , radiation therapy , physics , optics
Background The purpose of this study was to present our systematic review and meta‐analysis of the data on venous thromboembolism (VTE; deep venous thrombosis [DVT] and/or pulmonary embolism [PE]) in otolaryngology–head and neck surgery (OHNS). Methods PubMed and Scopus databases were searched for studies reporting VTE in OHNS. Incidence of VTE and bleeding is reported and meta‐analyzed overall and for chemoprophylaxis and squamous cell carcinoma (SCC)/free flap subgroups. Results A total of 23 studies were included with a total of 618,264 patients. Incidence of VTE was 0.4%. The incidence of bleeding complications was 0.9%. The addition of chemoprophylaxis did not result in a decreased VTE incidence (odds ratio [OR], 0.86), but produced an increased risk of bleeding (OR, 3.78). The overall OR for VTE in SCC/free flap cases was 6.28. Conclusion Chemoprophylaxis may not be necessary in the OHNS non‐SCC or free flap patient population and must be balanced against an increased risk of bleeding. © 2017 Wiley Periodicals, Inc. Head Neck 39: 1249–1258, 2017