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A variation in recurrence patterns of papillary thyroid cancer with disease progression: A long‐term follow‐up study
Author(s) -
Lee JoonHyop,
Chung Yoo Seung,
Lee Young Don
Publication year - 2017
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.24684
Subject(s) - medicine , distant metastasis , papillary thyroid cancer , thyroid cancer , metastasis , cancer recurrence , head and neck , cancer , disease , thyroid , head and neck cancer , surgery
Background Studies effectively examining temporal patterns of papillary thyroid cancer (PTC) recurrence are currently lacking. The purpose of this study was to examine sites of PTC recurrence, interval from initial treatment to recurrence, and changing patterns of recurrence during long‐term follow‐up. Methods Records of 134 patients with PTC recurrence were analyzed retrospectively. Results The most common site of initial recurrence was the lateral neck. In 6.7% of patients, distant metastases occurred as initial recurrences. In 74%, recurrences occurred within the first 5 years of surgery, whereas in 5.2%, and 1.5%, recurrences occurred between 10 to 20 years and after 20 years of surgery, respectively. Mean time to recurrence and distant metastasis was 48.2 months and 92.5 months, respectively. Male sex ( p = .002), size ( p < .001), N classification ( p < .001), and recurrence frequency ( p = .049) were prognostic factors for distant recurrence. Conclusion Men with PTC tumors larger than 2 cm, lateral neck node metastasis, and multiple local recurrences should be scrutinized for distant metastasis even after 10 years. © 2017 Wiley Periodicals, Inc. Head Neck 39: 767–771, 2017